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BMS Acquires Orum’s ADC Protein Degrader for $100M Upfront

ORM-6151 is a first-in-class, anti-CD33 antibody-enabled GSPT1 degrader cleared for Phase 1 for the treatment of AML or myelodysplastic syndromes.

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By: Kristin Brooks

Managing Editor, Contract Pharma

Orum Therapeutics, a clinical-stage biotechnology company pioneering Dual-Precision Targeted Protein Degradation (TPD²) and Targeted Protein Stabilization (TPS²), entered into a definitive agreement under which Bristol Myers Squibb has acquired Orum’s ORM-6151 program for $100 million upfront. Orum is eligible to receive milestone payments for a total deal value of $180 million.    ORM-6151 is a first-in-class, anti-CD33 antibody-enabled GSPT1 degrader that has received the FDA’s clearance for...

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